Background: High fats in diet are often considered as a root cause for metabolic
alterations which turns to lead obesity, a serious health problem in developed countries..
Obesity is characterized as abnormal storage of fats in adipose tissue, which appear as a
bodyweight beyond to the limit. It negatively affects diverse aspects of health and strongly
correlated with other complications like diabetes type 2 and heart diseases.
Objective: The study aimed to evaluate the manifestations of high fat diet on physiological
changes undergoing in the body and their association in developing obesity.
Method: Study conducted on male wistar rats, treated with high fats for 5 weeks to produce the animal model
of obesity. Food intake, Body weight, activity in familiar (home cage) and novel (open field) environment
were monitored once per week which was shown disturbed in animal model of obesity.
Results: The consumption of fats causes disturbance in food intake and appeared as positively associated with
body weight gain and obesity. Locomotor activity was found significantly decreased in animals consuming fat
rich diet as it was expected. Fat diet also produced anxiogenic behavior in animals as the time spent in light
box was decreased with the long term treatment.
Conclusion: This pre clinical trial suggests that the diet with strong fat profile can be a big promoter of
adiposity with different health hazards.