Background: Both Bipolar Disorder (BD) and Obsessive Compulsive Disorder (OCD) are chronic
psychiatric conditions, the first characterized by depressive and manic mood episodes and the latter
characterized by obsessions and compulsions. The comorbidity between BD and OCD is not rare, and the
presence of both conditions conveys important complications. The treatment supposes a challenge since
antidepressants, first choice of treatment for OCD, carry an important risk for bipolar patients.
Objective: In the present review our aim was to find evidence on Quetiapine's efficacy in the treatment of
bipolar disorder with comorbid OCD. Method: We performed a literature review on the treatment options for
comorbid BD and OCD, Quetiapine’s use in OCD and anxiety disorders and finally a MEDLINE search about
the use of Quetiapine for this specific indication.
Conclusion: The use of Quetiapine could be justified in patients with cycling OCD and in those who have
shown benefit from this antipsychotic for BD and can tolerate adjunctive antidepressants. Still, clinical trials
including this specific comorbid population should be performed to consider Quetiapine as part of BD-OCD