BAFFling Autoimmune Disorders and Helicobacter pylori Disease: The Interplay between BAFF and the Th17 Response

Author(s): Marina de Bernard , Mario Milco D’Elios .

Journal Name: Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued)

Volume 2 , Issue 1 , 2015

Abstract:

Besides regulating the humoral immunity, the B cell activating factor (BAFF) has also a crucial role in promoting pathogenic Th17 cell responses: the activity of the cytokine is manifested in autoimmune disorders but also in the inflammatory disease caused by the bacterium Helicobacter pylori. Thus, current evidence suggests that BAFF antagonism may be efficacious in Th17 cell-driven diseases.

Keywords: Autoimmune disorders, BAFF, Helicobacter pylori, Sjogren’s syndrome, Th17 response, TNF.

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2015
Page: [4 - 5]
Pages: 2
DOI: 10.2174/221270700201151216151928

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