Delivery of Peptides Via the Oral Route: Diabetes Treatment by Peptide-Loaded Nanoparticles

Author(s): Oriane Bouttefeux, Ana Beloqui, Veronique Preat.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 9 , 2016

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Abstract:

Over the last years, the interest of the pharmaceutical industry in the use of therapeutic peptides in diabetes treatment has been increased. However, these are restricted to parenteral administration. In order to mimic the natural physiological response, many efforts have been made towards oral peptide delivery in diabetes treatment. This review article aims to give an overview on the progress in the nanomedicine field towards the design and optimization of nanoparticle-based drug delivery systems capable of overcoming the harsh gastrointestinal environment and achieving an adequate bioavailability following oral administration. The reported data clearly illustrate the promise of nanomedicine for antidiabetic oral peptide delivery.

Keywords: Nanoparticles, nanomedicine, peptides, diabetes, insulin, incretin, GLP-1.

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Article Details

VOLUME: 22
ISSUE: 9
Year: 2016
Page: [1161 - 1176]
Pages: 16
DOI: 10.2174/1381612822666151216150238
Price: $58

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