Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores

Author(s): Amna M. Abdella, Ahmed H. M. Elwahy, Ismail A. Abdelhamid.

Journal Name: Current Organic Synthesis

Volume 13 , Issue 4 , 2016

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Abstract:

An efficient and convenient route for synthesis of novel bis 4H-chromene-3- carbonitrile derivatives is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated.

Keywords: Bis-aldehydes, bis-arylidenemalononitriles, multicomponent reactions, Bis-4H-chromene-3-carbonitriles.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2016
Page: [601 - 610]
Pages: 10
DOI: 10.2174/1570179413999151211115100
Price: $58

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