Title:Brønsted Acid Catalyzed Peptide Synthesis through Azlactone Rings
VOLUME: 13 ISSUE: 3
Author(s):Pedro P. De Castro, Igor F. Dos Santos and Giovanni W. Amarante
Affiliation:Department of Chemistry, Federal University of Juiz de Fora, Cidade Universitária, São Pedro, 36036-900, Juiz de Fora, MG, Brazi.
Keywords:Azlactones, peptides, amino acids, organocatalysis, Brønted acid, (+/-)-camphorsulfonic acid.
Abstract:Brønsted acid catalyzed azlactone ring opening by amino acids leading to the synthesis of dipeptides is
presented. Eleven compounds were synthesized in good to excellent isolated yields. Catalyst loading revealed that
5.0 mol % of (+/-)-CSA as an organocatalyst, under room temperature for 24 h, was suitable to promote this transformation.
