Brønsted Acid Catalyzed Peptide Synthesis through Azlactone Rings

Author(s): Pedro P. De Castro, Igor F. Dos Santos, Giovanni W. Amarante.

Journal Name: Current Organic Synthesis

Volume 13 , Issue 3 , 2016

Become EABM
Become Reviewer

Abstract:

Brønsted acid catalyzed azlactone ring opening by amino acids leading to the synthesis of dipeptides is presented. Eleven compounds were synthesized in good to excellent isolated yields. Catalyst loading revealed that 5.0 mol % of (+/-)-CSA as an organocatalyst, under room temperature for 24 h, was suitable to promote this transformation.

Keywords: Azlactones, peptides, amino acids, organocatalysis, Brønted acid, (+/-)-camphorsulfonic acid.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 3
Year: 2016
Page: [440 - 444]
Pages: 5
DOI: 10.2174/1570179413999151211114542
Price: $58

Article Metrics

PDF: 18
HTML: 1
EPUB: 1
PRC: 1