Benzofuran Small Molecules as Potential Inhibitors of Human Protein Kinases. A Review

Author(s): Halina Kwiecień, Agata Goszczyńska, Paulina Rokosz.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 7 , 2016

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Abstract:

Kinases are known to regulate the majority of human cellular processes such as communication, division, metabolism, survival and apoptosis therefore they can be promising targets in cancer diseases, viral infection and in other disorders. Small molecules acting as selective human protein kinase inhibitors are very attractive pharmacological targets. This review presents a number of examples of biologically active natural and synthetic benzo[b]furans and their derivatives, such as benzo[b]furan-2- and 3-ones, benzo[b]furan-2- and 3-carboxylic acids, as well as benzo[c]furans as potential inhibitors of various human protein kinases. The pathways of function and implication of the inhibitors in cancer and other diseases are discussed.

Keywords: Kinase, inhibitor, anti-cancer, benzo[b]furan, benzo[c]furan, biological activity.

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Article Details

VOLUME: 22
ISSUE: 7
Year: 2016
Page: [879 - 894]
Pages: 16
DOI: 10.2174/1381612822666151209152457
Price: $58

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