Molecular Mechanisms of Drug Photodegradation and Photosensitization

Author(s): Mohd Rehan Zaheer, Anamika Gupta, Jawaid Iqbal, Qamar Zia, Akil Ahmad, Roohi, Mohammad Owais, Ali Hashlamon, Siti Hamidah Mohd Setapar, Ghulam Md Ashraf, Gjumrakch Aliev.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 7 , 2016

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Abstract:

Drug-induced photosensitivity of the skin is drawing increasing attention. In past few decades, photosensitivity has been reported with an array of drugs, and is now recognized as a noteworthy medical problem by clinicians, regulatory authorities and pharmaceutical industry. The photosensitivity is of two types i.e., phototoxicity and photoallergy. Phototoxic disorders have a high incidence, whereas photoallergic reactions are much less frequent in human population. Several hundred substances, chemicals, or drugs may invoke phototoxic and photoallergic reactions. In order to avoid photosensitive reactions, it is essential to understand the mechanism behind the photosensitizing properties of such substances before these drugs are introduced in clinical settings. Photosensitization is inter-related to photochemical reaction, through the knowledge of which the photosensitivity of a drug can be anticipated. This review highlights the current research status on photosensitizing drugs and its correlation to phototoxicity. Different mechanisms of photodegradation of photolabile drugs have also been discussed.

Keywords: Drug, photoallergy, photodegradation, photosensitization, phototoxicity.

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Article Details

VOLUME: 22
ISSUE: 7
Year: 2016
Page: [768 - 782]
Pages: 15
DOI: 10.2174/1381612822666151209151408
Price: $58

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