Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells

Author(s): Conrad R.Y. Cruz, Catherine M. Bollard.

Journal Name: Current Drug Targets

Volume 18 , Issue 3 , 2017

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Graphical Abstract:


The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T cell therapeutics with a focus on how the manufacturing strategies have been refined, and where the research is heading.

Keywords: Cell therapy, leukemia antigens, ex vivo expanded T cells.

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Article Details

Year: 2017
Page: [271 - 280]
Pages: 10
DOI: 10.2174/1389450117666160209143529
Price: $58

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PDF: 24