Abstract
Rare pentoses, especially L-rare pentoses, have been attracting increasing attention because of their medicinal applications in antiviral and anticancer therapy, where they are used to produce L-nucleoside analogues. To address the problems of low natural abundance and limited synthetic methods for rare pentoses, biological synthesis has emerged recently as promising routes to these valuable compounds. This review summarizes enzymatic synthesis and whole cell microbial transformations of seven rare pentoses (L-ribulose, L-ribose, Lxylulose, L-xylose, L-lyxose, D-lyxose, D-xylulose) and two sugar alcohols (xylitol, L-arabinitol) as well as their interconversions. Examples of improving existing enzymes and discovering new systems are also discussed as advancements in genomics and bioengineering.
Keywords: Rare sugars, pentose, biosynthesis, microorganism, enzyme.
Current Organic Chemistry
Title:Synthesis of Rare Pentoses Using Microbial and Enzymatic Reactions
Volume: 20 Issue: 14
Author(s): Zijie Li, Xiao-Dong Gao and Li Cai
Affiliation:
Keywords: Rare sugars, pentose, biosynthesis, microorganism, enzyme.
Abstract: Rare pentoses, especially L-rare pentoses, have been attracting increasing attention because of their medicinal applications in antiviral and anticancer therapy, where they are used to produce L-nucleoside analogues. To address the problems of low natural abundance and limited synthetic methods for rare pentoses, biological synthesis has emerged recently as promising routes to these valuable compounds. This review summarizes enzymatic synthesis and whole cell microbial transformations of seven rare pentoses (L-ribulose, L-ribose, Lxylulose, L-xylose, L-lyxose, D-lyxose, D-xylulose) and two sugar alcohols (xylitol, L-arabinitol) as well as their interconversions. Examples of improving existing enzymes and discovering new systems are also discussed as advancements in genomics and bioengineering.
Export Options
About this article
Cite this article as:
Li Zijie, Gao Xiao-Dong and Cai Li, Synthesis of Rare Pentoses Using Microbial and Enzymatic Reactions, Current Organic Chemistry 2016; 20 (14) . https://dx.doi.org/10.2174/1385272820666151207190715
DOI https://dx.doi.org/10.2174/1385272820666151207190715 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Peptide Aptamers: Development and Applications
Current Topics in Medicinal Chemistry Protein-based Strategies of Molecular Therapy in Allergy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Current Treatment Strategies for Multiple Sclerosis - Efficacy Versus Neurological Adverse Effects
Current Pharmaceutical Design Targeting mTOR Pathways in Human Malignancies
Current Pharmaceutical Design Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy
Current Pharmaceutical Design Impact of the Somatotrope Growth Hormone (GH)/Insulin-Like Growth Factor 1 (IGF-1) Axis Upon Thymus Function: Pharmacological Implications in Regeneration of Immune Functions
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) A Knock-Down Cell-Based Study for the Functional Analysis of Chloride Intracellular Channel 1 (CLIC1): Integrated Proteomics and Microarray Study
Protein & Peptide Letters Understanding the Role of Aldose Reductase in Ocular Inflammation
Current Molecular Medicine Aquaporin and Vascular Diseases
Current Neuropharmacology Clinical Pharmacogenetics of Methotrexate
Current Drug Metabolism Fluoroquinolones in Pediatrics
Current Drug Therapy Biliary Innate Immunity in the Pathogenesis of Biliary Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Pharmacological Strategies for Inhibition of Thrombin Activity
Current Pharmaceutical Design Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants
Current Drug Metabolism “What Is And What Should Never Be”<sup>#</sup>: Use and Misuse of HPV Testing in Cervical Cancer Prevention Strategies
Current Women`s Health Reviews Patent Selections
Recent Patents on Drug Delivery & Formulation The Fallacy of the Longevity Elixir: Negligible Senescence May be Achieved, but Not by Using Something Physical
Current Aging Science Application of Pharmacogenomics to Dietary Cancer Chemoprevention
Current Pharmacogenomics Melatonin Therapy of Pediatric Sleep Disorders: Recent Advances, Why it Works, Who are the Candidates and How to Treat
Current Pediatric Reviews New Targeted Therapies for Thyroid Cancer
Current Genomics