LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

Author(s): Miryam Nava Catorce, Goar Gevorkian.

Journal Name: Current Neuropharmacology

Volume 14 , Issue 2 , 2016

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Abstract:

Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer´s disease (AD), Parkinson´s disease (PD), frontotemporal dementia and amyotrophic lateral sclerosis. Based on current knowledge in the field, suggesting that targeting peripheral inflammation could be a promising additional treatment/prevention approach for neurodegenerative diseases, drugs and natural products with anti-inflammatory properties have been evaluated in animal models of neuroinflammation and neurodegeneration. In this review, we provide an extensive analysis of one of the most important and widely-used animal models of peripherally induced neuroinflammation and neurodegeneration - lipopolysaccharide (LPS)-treated mice, and address the data reproducibility in published research. We also summarize briefly basic features of various natural products, nutraceuticals, with known anti-inflammatory effects and present an overview of data on their therapeutic potential for reducing neuroinflammation in LPS-treated mice.

Keywords: Astrocytes, LPS, microglia, neurodegeneration, neuroinflammation, nutraceuticals.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2016
Page: [155 - 164]
Pages: 10
DOI: 10.2174/1570159X14666151204122017
Price: $58

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