Angelman Syndrome: Communication, Educational and Related Considerations

Angelman Syndrome: Communication, Educational and Related Considerations

Indexed in: EBSCO, Ulrich's Periodicals Directory

Individuals with Angelman Syndrome (AS) present many unique challenges to professionals, parents and others who are committed to maximizing individuals’ competence while ensuring them the best ...
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Clinical Features, Medical Issues, and Diagnostic Testing in Angelman Syndrome

Pp. 3-27 (25)

Jennifer M. Mueller and Charles A. Williams

Abstract

This chapter reviews the clinical and medical aspects of Angelman syndrome (AS) and the genetic mechanisms that create a deficiency of the function of UBE3A on the maternally-derived number 15 chromosome. Genetic mechanisms causing AS include cytogenetic deletions, imprinting center defects, paternal uniparental disomy and UBE3A mutations. We review the clinical criteria for the diagnosis of AS and discuss genetic confirmatory testing. The chapter explores the natural history and characteristic features of AS including severe developmental delay, speech impairment, gait ataxia, microcephaly, seizures, and unique behaviors. Finally, we will discuss the implications for learning and overall function.

Keywords:

Angelman syndrome, Behavior phenotype, Chromosome disorder, Chromosome 15, Developmental delay, Genetic imprinting, Intellectual deficiency, Neurogenetics, UBE3A gene.

Affiliation:

Division of Genetics and Metabolism, Department of Pediatrics, 1600 SW Archer Road, PO Box 100296, Gainesville, Florida 32610.