Recent Advances in Medicinal Chemistry

Volume: 2

Indexed in: EBSCO.

Recent Advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, ...
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Updated Report on Synthesis and Biological Properties of Oxadiazine-Based Heterocyclic Derivatives

Pp. 107-143 (37)

Xiufang Cao and Shaoyong Ke

Abstract

Oxadiazine scaffold-based compounds are undoubtedly an important class of heterocyclic derivatives, which always present diverse bioactivities including cardiovascular, antitumor, antiviral, anti-leishmanial, antibacterial, antimicrobial, monoamine oxidase inhibition, acricidal, insecticidal, plant-growth regulating activities and chitin biosynthesis inhibitions. With the development of organic synthesis, versatile features of oxadiazine ring have emerged, so here we have reviewed the recent advances of oxadiazine-based heterocyclic derivatives mainly including preparation, transformation and biological properties, and this report is also an updated version of our previous review with modifications.

Keywords:

Oxadiazine, oxadiazinone, heterocyclic scaffold, synthetic method, pharmaceutical activity, pesticidal activity, biological application.

Affiliation:

National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, People`s Republic of China.