Drug Design and Discovery in Alzheimer’s Disease

Republished Version of Frontiers in Drug Design and Discovery Volume 6

Editor(s): Atta-ur-Rahman and Mohammad Iqbal Choudhary

Indexed in: Scopus and EMBASE

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Pharmacotherapy of Alzheimer's Disease: Current State and Future Perspectives

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Jan Korabecny, Filip Zemek, Ondrej Soukup, Katarina Spilovska, Kamil Musilek, Daniel Jun, Eugenie Nepovimova and Kamil Kuca


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Enzyme Inhibitors Involved in the Treatment of Alzheimer’s Disease

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Vageesh Revadigar, Raza Murad Ghalib, Vikneswaran Murugaiyah, Mohamed A. Embaby, Ali Jawad, Sayed Hasan Mehdi, Rokiah Hashim and Othman Sulaiman


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Towards Small Molecules as Therapies for Alzheimer’s Disease and Other Neurodegenerative Disorders

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Omar Aziz, Roland W. Bürli, David F. Fischer, Julie Frearson and Michael D. Wall


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Multifunctional Enzyme Inhibition for Neuroprotection - A Focus on MAO, NOS, and AChE Inhibitors

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Jacques Joubert, Jacobus P. Petzer, Louis H.A. Prins, Benjamin P. Repsold and Sarel F. Malan


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Specific Cholinesterase Inhibitors: A Potential Tool to Assist in Management of Alzheimer Disease

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Nigel H. Grieg, Mohammad A. Kamal, Nasimudeen R. Jabir, Shams Tabrez, Faizul H. Nasim, Adel M. Abuzenadah and Gjumrakch Aliev


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Role of Acetylcholinesterase Inhibitors and Alzheimer Disease

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Zafar Saied Saify and Nighat Sultana


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Research Strategies Developed for the Treatment of Alzheimer’s Disease. Reversible and Pseudo-Irreversible Inhibitors of Acetylcholinesterase: Structure-Activity Relationships and Drug Design

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Mauricio Alcolea-Palafox, Paloma Posada-Moreno, Ismael Ortuño- Soriano, José L. Pacheco-del-Cerro, Carmen Martínez-Rincón, Dolores Rodríguez-Martínez and Lara Pacheco-Cuevas


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BACE1 Inhibitors: Attractive Therapeutics for Alzheimer’s Disease

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Boris Decourt, MiMi Macias, Marwan Sabbagh and Abdu Adem


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Combining BACE1 Inhibition with Metal Chelation as Possible Therapy for Alzheimer’s Disease

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Maged M. Henary, Tyler L. Dost, Eric A. Owens and Surendra Reddy Punganuru


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Somatostatin Receptor-4 Agonists as Candidates for Treatment of Alzheimer’s Disease

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Karin E. Sandoval, Kenneth A. Witt, A. Michael Crider and Maria Kontoyianni


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Targeting the GSK3β/β-catenin Signaling to Treat Alzheimer´s Disease: Plausible or Utopic?

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Fares Zeidán-Chuliá and José Cláudio Fonseca Moreira


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Nanomedicine Based Drug Targeting in Alzheimer’s Disease: High Impact of Small Carter

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Mohammad Zaki Ahmad, Sohail Akhter, Ziyaur Rahman, Javed Ahmad, Iqbal Ahmad and Farhan Jalees Ahmad


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