Burn is the fourth most common type of trauma worldwide. It often creates a third degree to
fourth degree burn wound in the victims of accident. Hence a study was undertaken to fabricate hybrid
sponge with biopolymers, silver nano particle and phytochemical constituents to accelerate wound
healing. Antimicrobial susceptibility of wound isolates was evaluated by disc diffusion method. The
silver nano particle was synthesized using the extracts of clove bud. The size of silver nano material
ranged from 59-98 nm. The sponge was fabricated by freeze drying and its swelling property was evaluated. In the present
study, 82.3% of the swelling of the sponge was observed within 20 minutes. The efficiency of sponge in healing infectious
burn wound was assessed in rats. On the 20th day, 96.92% of wound was healed in sponge dressing and 58.2% in silverex
treated rats. Thus, the study proved that the sponge accelerated the healing rate. Recent patents on the formulation of antimicrobial
dressings and sponge have also been discussed in this paper.
Keywords: Acalyphaindica leaves, honey, Hybanthus, silver nano particles, sponge and in vivo burn wound healing.
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