Title:1-Hydroxypyranonaphthoquinones – Isolation, Bioactivity and Synthesis
VOLUME: 12 ISSUE: 5
Author(s):Christopher D. Donner
Affiliation:School of Chemistry, The University of Melbourne, Victoria 3010, Australia.
Keywords:1-hydroxy-1H-benzo[g]isochromene, 1-hydroxy-1H-naphtho[2, 3-c]pyran, fungal pigment, HRV 3C-protease, lactol,
naphthopyran, pyranonaphthoquinone, thysanone.
Abstract:A discussion of 1-hydroxypyranonaphthoquinones is presented that outlines the isolation and biological activity
of the known naturally occurring members of this class of compounds. Synthetic approaches developed towards 1-
hydroxypyranonaphthoquinones and analogues having potentially improved biological profiles are discussed with particular
emphasis on the HRV 3C-protease inhibitor thysanone.
