Nitric Oxide Synthases and Their Natural Inhibitors

Author(s): Christos Kontogiorgis, Dimitra Hadjipavlou-Litina.

Journal Name: Current Enzyme Inhibition

Volume 12 , Issue 1 , 2016

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Abstract:

Nitric Oxide (NO) is a molecule of extreme interest to biologists, pharmacologists, physiologists, and biochemists, characterized as a mediator in the cardiovascular system. It has been found to be implicated in various pathological processes. NO is synthesized enzymatically by Nitric Oxide Synthases (NOSs) from L-arginine, and therefore NOSs have emerged as very crucial therapeutic targets. Herein, a series of extracts from plants as well as a number of isolated compounds acting as NOS inhibitors are presented.

Keywords: Nitric oxide synthase inhibitors, naturally occurring NOS inhibitors, NOS inhibitors from plants, isolated natural compounds, extracts from plants.

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2016
Page: [3 - 15]
Pages: 13
DOI: 10.2174/1573408012666151126185628

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