Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A

Author(s): L. Wang , Y. Yang , X. -D. Gong , Z. -X. Huang , Q. Nie , Z. -F. Wang , W. -K. Ji , X. -H. Hu , W. -F. Hu , L. -L. Gong , L. Zhang , S. Huang , R. -L. Qi , T. -H. Yang , Z. -G. Chen , W. -B. Liu , Y. -Z. Liu , D. W. -C. Li .

Journal Name: Current Molecular Medicine

Volume 15 , Issue 10 , 2015

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The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.

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Article Details

Year: 2015
Page: [944 - 951]
Pages: 8
DOI: 10.2174/156652401510151125125127
Price: $58

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