Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A

Author(s): L. Wang , Y. Yang , X. -D. Gong , Z. -X. Huang , Q. Nie , Z. -F. Wang , W. -K. Ji , X. -H. Hu , W. -F. Hu , L. -L. Gong , L. Zhang , S. Huang , R. -L. Qi , T. -H. Yang , Z. -G. Chen , W. -B. Liu , Y. -Z. Liu , D. W. -C. Li .

Journal Name: Current Molecular Medicine

Volume 15 , Issue 10 , 2015

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer

Abstract:

The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 10
Year: 2015
Page: [944 - 951]
Pages: 8
DOI: 10.2174/156652401510151125125127
Price: $58

Article Metrics

PDF: 16
HTML: 2