Background: G protein coupled receptor 120 (GPR120) is a class of receptors in
the gastrointestinal tract (GIT) that is implicated in nutrient sensing and body weight regulation.
Functions of GPR120 are thought to be mediated by the release of a group of hormones known as
incretins, such as glucagon like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP).
Methods: We have searched PubMed with the keywords "GPR120","GLP-1" and "obesity". Relevant
studies were retrieved and included in the review.
Results: Recently, many exogenous compounds have been investigated in their role in the release of
GLP-1 and in causing weight loss in obese rats. However, some results question the putative role of
GPR120 in metabolic homeostasis.
Conclusion: Herein, we evaluate the potential use of GPR120 as a target receptor in obesity and found it to be ubiquitous
throughout the GIT, with various functions in each site. In order to find the optimal drug, the role of GPR120 in each site
needs to be defined and selectivity of the potential drug needs to be studied to ensure the success of this growing line of