A novel synthetic method of 4-substituted aryl-1H-1,2,3-triazoles from arylglyoxaldoxime
semicarbazone with sodium dithionite and O2 was found to be safer than the Huisgen azide–
alkyne dipolar cycloaddition. A total of 17 new structures of 4-substituted aryl-1H-1,2,3-
triazoles were characterized by 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro antihepatoma
activities were evaluated on human hepatoma QGY-7703, Bel-7402 and SMMC-7721
cell lines and mouse fibroblast cells L-929 by MTS assay. Among them, 5k exhibited excellent
activity against QGY-7703 (GI50 = 0.0232 μM), while 5p and 5q displayed good activity (GI50 =
0.103 μM and GI50 = 0.182 μM) against the growth of SMMC-7721 cell lines. Furthermore, 5k, 5p and 5q showed
slight selectivity of inhibition on hepatoma cell lines over normal cell line L-929.
Keywords: Synthesis, anti-hepatoma activity, sodium dithionite, O2, 4-aryl-1H-1, 2, 3-triazoles, anti-hepatoma activity.
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