Targeted Drug Delivery System for Platinum-based Anticancer Drugs

Author(s): Chuanzhu Gao, Yan Zhang, Ji Chen, Tianshuai Wang, Yunxu Qian, Bo Yang, Peng Dong, Yingjie Zhang.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 16 , Issue 11 , 2016

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Abstract:

Platinum-based (Pt-based) anticancer drugs have been recognised as one of the most effective drugs for clinical treatment of malignant tumors due to its unique mechanism of action and broad range of anticancer spectrum. But, there are still some limitations such as side effects, drug resistance/cross resistance, no-specific targeting, becoming obstacles to restrict its expanding of clinical application. Targeted drug delivery system (TDDS) is a promising strategy for the research of novel Pt-based anticancer drugs. A variety of TDDS have been explored to improve the antitumor activity of Pt-based drugs such as nanoparticle drug systems, polymer-drug systems, drugs-macrocyclic compounds systems, etc. The review concentrates on recent development of various targeted drug delivery techniques, which could provide more opportunities for the development of Pt-based drugs with better efficiency, lower toxicity and less resistance.

Keywords: Anticancer, Drugs-macrocyclic compounds system, Nanoparticle drug system, Platinum-based drugs, Polymerdrug system, Review, Targeted drug delivery system.

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2016
Page: [872 - 891]
Pages: 20
DOI: 10.2174/1389557516666151120115947
Price: $58

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