Therapeutic Outlook of Pyrazole Analogs: A Mini Review

Author(s): Swastika Ganguly*, Sony K. Jacob.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 11 , 2017

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Abstract:

Background: Pyrazole is one of the excellent structural motifs in medicinal chemistry. Various physiological and therapeutic possibilities have been exploited by incorporating different pharmacophoric groups in the pyrazole moiety.

Objective: This has opened a new arena of pyrazole analogs that can be developed into medicinal agents such as anti-inflammatory, analgesic, antipyretic, antiviral, antibacterial, anticancer, anticonvulsant, hypoglycemic, carbonic anhydrase inhibitors, mono amino oxidase (MAO) inhibitors, etc. Though, pyrazole analogs have proven their clinical efficacy as different pharmacological agents, a few of them have been withdrawn from the market due to their side effects. Thus, research on potential new drug candidates bearing the pyrazole moiety with lesser side effects has fairly increased over the last few years.

Conclusion: This review explores diverse pharmacological activities exhibited by pyrazole analogs reported recently, which may be of great help for researchers in the area of drug discovery to understand the current scenario of pyrazole based compounds and to design and develop newer drug candidates with improved efficacy.

Keywords: Analgesic, antibacterial, anticancer, anti-inflammatory, antipyretic, antiviral, pyrazole.

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Article Details

VOLUME: 17
ISSUE: 11
Year: 2017
Page: [959 - 983]
Pages: 25
DOI: 10.2174/1389557516666151120115302
Price: $58

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