Secretome Analysis of a Pseudomonas aeruginosa Strain Grown Under High Alkane Stress

Author(s): R. Hemamalini, Sunil Kumar Khare.

Journal Name: Current Proteomics

Volume 12 , Issue 3 , 2015

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Graphical Abstract:


The effect of alkanes, viz. n-hexane, n-heptane and n-octane on the extracellular proteome and secretome of a solvent tolerant Pseudomonas aeruginosa has been described. Superoxide dismutase, GroEL, A-type flagellin and the porin OprF were altered significantly. The presence of these proteins in the extracellular proteome of solvent-grown cells indicates their role in the cellular adaptation of the strain to a high alkane environment. Up regulation of superoxide dismutase indicates creation of oxidative stress for the bacterial cell in an alkane-rich environment. This secretome analysis is useful for gaining a better understanding of the solvent mediated oxidative stress and the role of superoxide dismutase and GroEL expression as possible markers of solvent tolerance.

Keywords: Elastase, endopeptidase, OprF, GroEL, superoxide dismutase, solvent tolerance.

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Article Details

Year: 2015
Page: [202 - 208]
Pages: 7
DOI: 10.2174/157016461203151120094228
Price: $58

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