Restless legs syndrome is an underdiagnosed sensori-motor disorder and psychotropic drugs are one of the
main secondary causes of the illness. The most common psychotropic agents that cause restless legs syndrome are
antidepressants; however, antipsychotics have also been reported to induce restless legs syndrome. The prevalence,
vulnerability factors and the underlying mechanism of antipsychotic-induced restless legs syndrome are unclear. A
possible explanation is that dopaminergic blockade is the main precipitator of the syndrome. Quetiapine-induced restless
legs syndrome is another point of interest because of its low binding to D2 receptors. We herein report the case of a
restless legs syndrome that emerged after a single low dose quetiapine administration.
Keywords: Restless legs syndrome, clozapine, psychotropic drugs, quetiapine, risperidone.
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