Synthesis, Structural Characterization of a Novel Ferrocene Derivative and Preliminarily Anticancer Activity

Author(s): Jianping Yong, Xiaoyuan Wu, Jianzhen Liao, Canzhong Lu, Xiaolong Liu.

Journal Name: Medicinal Chemistry

Volume 12 , Issue 5 , 2016

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Abstract:

A novel structure of ferrocene derivative 1 was synthesized with cyanuric chloride and ferrocenemethanol as starting materials. The synthesized compound was fully characterized using 1H NMR, 13C NMR, MS and XRD. Subsequently, the in vitro anticancer effect against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated by the MTT method. The result showed that this compound exhibits good cytotoxic effect on A549, HCT116 and MCF-7 cell lines.

Keywords: Ferrocene derivative, synthesis, characterization, NMR, XRD, anticancer activity.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2016
Page: [426 - 431]
Pages: 6
DOI: 10.2174/1573406412666151112125345
Price: $58

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