Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues

Author(s): Zhen-Jun Wang, Hui-Hui Yang, Lei Tian, Wei-Guang Zhao.

Journal Name: Medicinal Chemistry

Volume 12 , Issue 3 , 2016

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Abstract:

Succinate dehydrogenase inhibitors (SDHIs) are fungicides with an amide bond widely used to control plant diseases caused by phytopathogenic fungi. Because of broad spectrum activity of new SDHIs, they have attracted wide attention from the research community. A series of structurally novel SDHIs with a bioactive 1,2,3-triazole moiety were designed and synthesized. Bioactivity screening showed that some of designed N-phenethyl-1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Sclerotinia sclerotiorum and Botrytis cinerea, while some of Nbenzyl- 1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Phytophthora capsici and Cercospora arachidicola. EC50 value of compound 5d against Cercospora arachidicola (6.6 µg/mL) was lower than that of chlorothalonil (12.3 µg/mL).

Keywords: Succinate dehydrogenase inhibitors, 1, 2, 3-Triazole, fungicide, fungicidal activity relationship, synthesis.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2016
Page: [290 - 295]
Pages: 6
DOI: 10.2174/1573406412666151112125006
Price: $65

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