Succinate dehydrogenase inhibitors (SDHIs) are fungicides with an amide bond widely
used to control plant diseases caused by phytopathogenic fungi. Because of broad spectrum activity of
new SDHIs, they have attracted wide attention from the research community. A series of structurally
novel SDHIs with a bioactive 1,2,3-triazole moiety were designed and synthesized. Bioactivity screening
showed that some of designed N-phenethyl-1,2,3-trizole-4-carboxyl amide analogues exhibited
good fungicidal activities toward Sclerotinia sclerotiorum and Botrytis cinerea, while some of Nbenzyl-
1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Phytophthora
capsici and Cercospora arachidicola. EC50 value of compound 5d against Cercospora arachidicola (6.6 µg/mL)
was lower than that of chlorothalonil (12.3 µg/mL).
Keywords: Succinate dehydrogenase inhibitors, 1, 2, 3-Triazole, fungicide, fungicidal activity relationship, synthesis.
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