Vascular effects of flavonoids

Author(s): Bruno Almeida Rezende, Aline Carvalho Pereira, Steyner F. Cortes, Virginia Soares Lemos.

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 1 , 2016

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Abstract:

Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.

Keywords: Cardiovascular system, flavonoids, mechanism, natural products, signaling pathway, vascular effects, vasorelaxation.

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Article Details

VOLUME: 23
ISSUE: 1
Year: 2016
Page: [87 - 102]
Pages: 16
DOI: 10.2174/0929867323666151111143616

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