Recent Advances in Alzheimer Research

Recent Advances in Alzheimer Research

Volume: 1

Common Pathogenic Mechanisms between Down Syndrome and Alzheimer`s Disease Steps toward Therapy

Indexed in: EBSCO.

Recent Advances in Alzheimer Disease Research is a book series focusing on contemporary research on Alzheimer’s disease epidemiology, pathophysiology, diagnosis and therapy. The series features ...
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Neuropathological Phenotype in Alzheimer’s Disease and Down Syndrome: Chemical Nature and Anatomical Localization

Pp. 151-172 (22)

Laura J. Pulford, Sarah Müller, Frances K. Wiseman and Amy M. Pooler

Abstract

Alzheimer’s disease (AD) is characterized by progressive pathological changes in the brain, including accumulation of protein aggregates such as amyloid plaques and neurofibrillary tangles (NFTs). Deposition of these proteins leads to widespread neuronal loss and subsequent cognitive decline. AD-associated pathology also develops in individuals with Down syndrome (DS) and is generally found to precede onset of dementia symptoms. In this chapter, we discuss progressive development of AD pathology, including plaques, NFTs, synaptic dysfunction, neuronal loss, and brain atrophy. Furthermore, we examine similarities and differences in these pathologies between AD and AD/DS. Finally, we review several genetic factors that may contribute to the development of AD.

Keywords:

Amyloid plaques, Down syndrome, neurofibrillary tangles, neurodegeneration, tau, trisomy 21.

Affiliation:

King`s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.