Proteases and their Inhibitors: From Basic to High Throughput Screening
Proteases constitute one of the most important groups of industrial
enzymes with a worldwide value expected to reach 2.7 billion US dollars by 2019.
Proteases represent a group of enzymes that hydrolyze the peptide bonds of proteins,
releasing polypeptides or free amino acids. These enzymes are used in cleaning
products, production of leathers, textiles, food and dairy products, in the
pharmaceutical and diagnostic industries and for water treatment. Another area of
interest regarding proteases is the development of drugs that act as protease
inhibitors. This review will briefly describe the general methods used in the detection
of proteases and the few studies in the development of high throughput screening
methods of proteases and protease inhibitors.
Keywords: Proteases, inhibitors, high throughput screening.
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