When designing clinical trials for testing novel cardiovascular therapies, it is highly relevant to understand
what a given technology can provide in terms of information on the physiologic status of the heart and vessels.
Ultrasound imaging has traditionally been the modality of choice to study the cardiovascular system as it has
an excellent temporal resolution; it operates in real-time; it is very widespread and - not unimportant - it is cheap.
Although this modality is mostly known clinically as a two-dimensional technology, it has recently matured into a
true three-dimensional imaging technique. In this review paper, an overview is given of the available ultrasound
technology for cardiac chamber quantification in terms of volume and function and evidence is given why these parameters
are of value when testing the effect of new cardiovascular therapies.
Keywords: Cardiac function, Cardiac volume, 3D echocardiography, Segmentation, Automated analysis, Commercial solutions, Validation
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