Abstract
Hybrid imaging devices including PET/CT and SPECT/CT have seen a great success since these scanners found their way into clinical routine – although this success is mainly based on the use in oncological imaging. But also the advent of PET/MRI holds great promise. The combined assessment of molecular imaging and morphology making use of the variety of PET tracers and the high spatial resolution from CT or MRI has the potential of an increased diagnostic accuracy all imaging but especially in cardiovascular questions. We put special emphasis on PET/MR although the experience is still limited. However, as the use of MR imaging in the assessment of myocardial viability as a prime example where assessing myocardial metabolism – even if done so indirectly - is so widespread in clinical reality, this appears to be justified. Thus, in this review, we aim to outline technical characteristics of hybrid imaging systems and highlight their use in cardiovascular diseases and their applications.
Keywords: PET, cardiac imaging, metabolism, perfusion, hybrid imaging, PET/MR, PET/CT, attenuation correction, workflows, dynamic imaging.
Current Pharmaceutical Design
Title:Assessing Myocardial Metabolism with Hybrid PET Imaging: Instrumentation, Concepts, and Workflows
Volume: 22 Issue: 1
Author(s): Stephan G. Nekolla and Christoph Rischpler
Affiliation:
Keywords: PET, cardiac imaging, metabolism, perfusion, hybrid imaging, PET/MR, PET/CT, attenuation correction, workflows, dynamic imaging.
Abstract: Hybrid imaging devices including PET/CT and SPECT/CT have seen a great success since these scanners found their way into clinical routine – although this success is mainly based on the use in oncological imaging. But also the advent of PET/MRI holds great promise. The combined assessment of molecular imaging and morphology making use of the variety of PET tracers and the high spatial resolution from CT or MRI has the potential of an increased diagnostic accuracy all imaging but especially in cardiovascular questions. We put special emphasis on PET/MR although the experience is still limited. However, as the use of MR imaging in the assessment of myocardial viability as a prime example where assessing myocardial metabolism – even if done so indirectly - is so widespread in clinical reality, this appears to be justified. Thus, in this review, we aim to outline technical characteristics of hybrid imaging systems and highlight their use in cardiovascular diseases and their applications.
Export Options
About this article
Cite this article as:
G. Nekolla Stephan and Rischpler Christoph, Assessing Myocardial Metabolism with Hybrid PET Imaging: Instrumentation, Concepts, and Workflows, Current Pharmaceutical Design 2016; 22 (1) . https://dx.doi.org/10.2174/1381612822666151109112519
DOI https://dx.doi.org/10.2174/1381612822666151109112519 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacogenetically Tailored Treatments for Heart Disease
Current Pharmaceutical Design Therapeutic and Protective Potential of Mesenchymal Stem Cells, Pharmaceutical Agents and Current Vaccines Against COVID-19
Current Stem Cell Research & Therapy Lipid Resuscitation: A Life-Saving Antidote for Local Anesthetic Toxicity
Current Pharmaceutical Biotechnology Sacubitril/Valsartan: A New Dawn has Begun! A Revisited Review
Current Cardiology Reviews Identification of Bioactive Natural Products by Pharmacophore-Based Virtual Screening
Current Pharmaceutical Design Diabetes and Heart Failure: Is it Hyperglycemia or Hyperinsulinemia?
Current Vascular Pharmacology Status Epilepticus: An Overview
Current Drug Metabolism Synthesis and Pharmacological Profile of a Series of 1-substituted-2-Carbonyl Derivatives of Diphenidol: Novel M4 Muscarinic Receptor Antagonists
Medicinal Chemistry Impact of CYP2D6 Genetic Variation on the Response of the Cardiovascular Patient to Carvedilol and Metoprolol
Current Drug Metabolism Perioperative Considerations in Rheumatoid Arthritis Patients
Current Rheumatology Reviews Free Radicals in Diseases and Potential Role of Phytoconstituents-A Cause with Emerging Importance
Current Chemical Biology Novel Drug Targets for the Treatment of Cardiac Diseases
Current Pharmacogenomics and Personalized Medicine L-Type Calcium Channels
Current Pharmaceutical Design Methods for Docking Small Molecules to Macromolecules: A User’s Perspective. 2. Applications
Current Pharmaceutical Design Balancing the Risks of Thrombosis and Bleeding Following Transcatheter Aortic Valve Implantation: Current State-of-Evidence
Current Pharmaceutical Design Advanced Echocardiographic Imaging of the Congenitally Malformed Heart
Current Cardiology Reviews Treatment of the Cheyne-Stokes Breathing Pattern in Patients with Congestive Heart Failure: State of the Art
Current Respiratory Medicine Reviews Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnoea Syndrome and Overlap Syndrome
Current Vascular Pharmacology A Review of Feature Extraction from ECG Signals and Classification/ Detection for Ventricular Arrhythmias
Recent Advances in Computer Science and Communications Cannabinoids and Cardiovascular Disease: The Outlook for Clinical Treatments
Current Vascular Pharmacology