Activation of Mitochondrial Uncoupling Protein 4 and ATP-Sensitive Potassium Channel Cumulatively Decreases Superoxide Production in Insect Mitochondria

Author(s): Malgorzata Slocińska, Grzegorz Rosinski, Wieslawa Jarmuszkiewicz.

Journal Name: Protein & Peptide Letters

Volume 23 , Issue 1 , 2016

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Abstract:

It has been evidenced that mitochondrial uncoupling protein 4 (UCP4) and ATP-regulated potassium channel (mKATP channel) of insect Gromphadorhina coqereliana mitochondria decrease superoxide anion production. We elucidated whether the two energy-dissipating systems work together on a modulation of superoxide level in cockroach mitochondria. Our data show that the simultaneous activation of UCP4 by palmitic acid and mKATP channel by pinacidil revealed a cumulative effect on weakening mitochondrial superoxide formation. The inhibition of UCP4 by GTP (and/or ATP) and mKATP channel by ATP elevated superoxide production. These results suggest a functional cooperation of both energy-dissipating systems in protection against oxidative stress in insects.

Keywords: Insects, mitochondria, mitochondrial ATP-regulated channel (mKATP channel), superoxide production, uncoupling protein 4 (UCP4).

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Article Details

VOLUME: 23
ISSUE: 1
Year: 2016
Page: [63 - 68]
Pages: 6
DOI: 10.2174/0929866523666151106121943

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