It has been evidenced that mitochondrial uncoupling protein 4 (UCP4) and ATP-regulated
potassium channel (mKATP channel) of insect Gromphadorhina coqereliana mitochondria decrease
superoxide anion production. We elucidated whether the two energy-dissipating systems work together
on a modulation of superoxide level in cockroach mitochondria. Our data show that the simultaneous
activation of UCP4 by palmitic acid and mKATP channel by pinacidil revealed a cumulative effect on
weakening mitochondrial superoxide formation. The inhibition of UCP4 by GTP (and/or ATP) and
mKATP channel by ATP elevated superoxide production. These results suggest a functional cooperation
of both energy-dissipating systems in protection against oxidative stress in insects.
Keywords: Insects, mitochondria, mitochondrial ATP-regulated channel (mKATP channel), superoxide production, uncoupling
protein 4 (UCP4).
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