In the past few decades, there has been great interest in the monofunctionalization of
inorganic nanoparticles using organic chemistry tool. However, the uncontrollability in the degree
of nanoparticle functionalization and the number of functional groups on the nanoparticles
restrict their applications. It is now realized that precisely controlling the composition of the
nanoparticles (NPs) will be of great importance for many biomedical applications. In this review,
we will focus on using organic chemistry tools for monofunctionalization of inorganic nanoparticles,
biomedical applications of monofunctionalized NPs, and then also discuss recent advances
and future prospects in this emerging field.
Keywords: Organic chemistry tool, inorganic nanoparticles, monofunctionalization, biomedical application.
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