Clinically Relevant Pharmacokinetic Herb-drug Interactions in Antiretroviral Therapy

Author(s): Pius S. Fasinu, Bill J. Gurley, Larry A. Walker.

Journal Name: Current Drug Metabolism

Volume 17 , Issue 1 , 2016

Become EABM
Become Reviewer

Abstract:

For healthcare professionals, the volume of literature available on herb-drug interactions often makes it difficult to separate experimental/potential interactions from those deemed clinically relevant. There is a need for concise and conclusive information to guide pharmacotherapy in HIV/AIDS. In this review, the bases for potential interaction of medicinal herbs with specific antiretroviral drugs are presented, and several botanicals are discussed for which clinically relevant interactions in humans are established. Such studies have provided, in most cases, sufficient ground to warrant the avoidance of concurrent administration of antiretroviral (ARVs) drugs with St John’s wort (Hypericum perforatum), black pepper (Piper species) and grapefruit juice. Other botanicals that require caution in the use with antiretrovirals include African potato (Hypoxis hemerocallidea), ginkgo (Ginkgo biloba), ginseng (Panax species), garlic (Allium sativum), goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum). The knowledge of clinically significant herb-drug interaction will be important in order to avoid herb-induced risk of sub-therapeutic exposure to ARVs (which can lead to viral resistance) or the precipitation of toxicity (which may lead to poor compliance and/or discontinuation of antiretroviral therapy).

Keywords: Antiretroviral therapy, drug metabolism, enzyme inhibition, herb-drug interaction, HIV/AIDS, grapefruit juice, pharmacokinetics, piperine, St John’s wort.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 17
ISSUE: 1
Year: 2016
Page: [52 - 64]
Pages: 13
DOI: 10.2174/1389200216666151103115053

Article Metrics

PDF: 125
HTML: 10
EPUB: 2
PRC: 1