Abstract
The major goal of bone tissue engineering is to develop bioconstructs which substitute the functionality of damaged natural bone structures as much as possible if critical-sized defects occur. Scaffolds that mimic the structure and composition of bone tissue and cells play a pivotal role in bone tissue engineering applications. First, composition, properties and in vivo synthesis of bone tissue are presented for the understanding of bone formation. Second, potential sources of osteoprogenitor cells have been investigated for their capacity to induce bone repair and regeneration. Third, taking into account that the main property to qualify one scaffold as a future bioconstruct for bone tissue engineering is the biocompatibility, the assessments which prove it are reviewed in this paper. Forth, various types of natural polymer- based scaffolds consisting in proteins, polysaccharides, minerals, growth factors etc, are discussed, and interaction between scaffolds and cells which proved bone tissue engineering concept are highlighted. Finally, the future perspectives of natural polymer-based scaffolds for bone tissue engineering are considered.
Keywords: Biocompatibility, bone, natural polymers, osteoprogenitor cells, scaffolds, tissue engineering.
Current Stem Cell Research & Therapy
Title:Natural Polymer-Cell Bioconstructs for Bone Tissue Engineering
Volume: 12 Issue: 2
Author(s): Irina Titorencu, Madalina Georgiana Albu, Miruna Nemecz and Victor V. Jinga
Affiliation:
Keywords: Biocompatibility, bone, natural polymers, osteoprogenitor cells, scaffolds, tissue engineering.
Abstract: The major goal of bone tissue engineering is to develop bioconstructs which substitute the functionality of damaged natural bone structures as much as possible if critical-sized defects occur. Scaffolds that mimic the structure and composition of bone tissue and cells play a pivotal role in bone tissue engineering applications. First, composition, properties and in vivo synthesis of bone tissue are presented for the understanding of bone formation. Second, potential sources of osteoprogenitor cells have been investigated for their capacity to induce bone repair and regeneration. Third, taking into account that the main property to qualify one scaffold as a future bioconstruct for bone tissue engineering is the biocompatibility, the assessments which prove it are reviewed in this paper. Forth, various types of natural polymer- based scaffolds consisting in proteins, polysaccharides, minerals, growth factors etc, are discussed, and interaction between scaffolds and cells which proved bone tissue engineering concept are highlighted. Finally, the future perspectives of natural polymer-based scaffolds for bone tissue engineering are considered.
Export Options
About this article
Cite this article as:
Titorencu Irina, Albu Georgiana Madalina, Nemecz Miruna and Jinga V. Victor, Natural Polymer-Cell Bioconstructs for Bone Tissue Engineering, Current Stem Cell Research & Therapy 2017; 12 (2) . https://dx.doi.org/10.2174/1574888X10666151102105659
DOI https://dx.doi.org/10.2174/1574888X10666151102105659 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
HSP70 Family in the Renal Inflammatory Response
Inflammation & Allergy - Drug Targets (Discontinued) Cocaine and Acute Vascular Diseases
Current Drug Abuse Reviews Anticoagulant Therapy in Pregnant Patients with Metabolic Syndrome: A Review
Current Pharmaceutical Biotechnology Twin-to-Twin Transfusion Syndrome: Diagnosis and Treatment
Current Women`s Health Reviews Contribution of Mast Cells to Cerebral Aneurysm Formation
Current Neurovascular Research Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Current Cancer Drug Targets A Review of the Management of Lymphangiomas
Current Pediatric Reviews Paving Roads for New Drugs in Oncology
Recent Patents on Anti-Cancer Drug Discovery Therapeutic Potential of Neuregulin in Cardiovascular System: Can we Ignore the Effects of Neuregulin on Electrophysiology?
Mini-Reviews in Medicinal Chemistry The Fragile X Family of Disorders: A Model for Autism and Targeted Treatments
Current Pediatric Reviews Pharmacological Treatment of Hypertension in Pregnancy
Current Pharmaceutical Design Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology A Feature-Free 30-Disease Pathological Brain Detection System by Linear Regression Classifier
CNS & Neurological Disorders - Drug Targets Integrins Modulate Cellular Fibrogenesis at Multiple Levels: Regulation of TGF-β Signaling
Endocrine, Metabolic & Immune Disorders - Drug Targets Molecular Genetics of Familial Exudative Vitreoretinopathy and Norrie Disease
Current Genomics Sonic Hedgehog, the Penis and Erectile Dysfunction: A Review of Sonic Hedgehog Signaling in the Penis
Current Pharmaceutical Design Regulatory Approaches to Nonclinical Reproductive Toxicity Testing of Anti-Cancer Drugs
Anti-Cancer Agents in Medicinal Chemistry Chest Pain in Children
Current Pediatric Reviews Cutaneomeningospinal Angiomatosis (Cobb Syndrome) in a Young Patient
CNS & Neurological Disorders - Drug Targets Tumour-Specific Uptake of Anti-Cancer Drugs: The Future is Here
Current Drug Metabolism