AMPK Function in Aging Process

Author(s): Rocío Ruiz, Eva María Pérez-Villegas, Ángel Manuel Carrión.

Journal Name: Current Drug Targets

Volume 17 , Issue 8 , 2016

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Abstract:

Aging involves the progressive deterioration of physiological functions, diminishing the individual’s capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved genetic and biochemical pathways represented an unprecedented advance in aging research. The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.

Keywords: AMPK, aging, metabolic dysfunction, stress oxidative, senescence.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2016
Page: [932 - 941]
Pages: 10
DOI: 10.2174/1389450116666151102095825
Price: $58

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