Among the difficulties encountered in the treatment of cancer are the physico-chemical
properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting
in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of
them) cyclodextrins constitute a powerful tool to prepare more efficient chemotherapeutic delivery
systems such as nanoparticles. This review focuses on polymeric nanoparticles for cancer therapy prepared
from either cyclodextrin molecules, or polymer and cyclodextrins.
Keywords: Cancer, cyclodextrins, nanoparticles, polymers, solubility, stability, cytotoxicity.
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