Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs

Author(s): Dominique Duchene , Roberta Cavalli , Ruxandra Gref .

Journal Name: Current Pharmaceutical Biotechnology

Volume 17 , Issue 3 , 2016

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Abstract:

Among the difficulties encountered in the treatment of cancer are the physico-chemical properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of them) cyclodextrins constitute a powerful tool to prepare more efficient chemotherapeutic delivery systems such as nanoparticles. This review focuses on polymeric nanoparticles for cancer therapy prepared from either cyclodextrin molecules, or polymer and cyclodextrins.

Keywords: Cancer, cyclodextrins, nanoparticles, polymers, solubility, stability, cytotoxicity.

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2016
Page: [248 - 255]
Pages: 8
DOI: 10.2174/1389201017666151030104944
Price: $58

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