Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged as important
regulators of the actin cytoskeleton and cytoskeleton-supported cell functions, such as migration and adhesion. The
effects of Nox-derived ROS on cytoskeletal remodeling may be largely attributed to the ability of ROS to directly
modify proteins that constitute or are associated with the cytoskeleton. Additionally, Nox-derived ROS may participate
in signaling pathways governing cytoskeletal remodeling. In addition to these more extensively studied
signaling pathways involving Nox-derived ROS, there also exist redox sensitive pathways for which the source of
ROS is unclear. ROS from as of yet undetermined sources play a role in modifying, and thus regulating, the activity
of several proteins critical for remodeling of the actin cytoskeleton. In this review we discuss ROS sensitive targets
that are likely to affect cytoskeletal dynamics, as well as the potential involvement of Nox proteins.
Keywords: Cytoskeleton, NADPH oxidase, ROS, oxidation, signaling.
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