The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics

Author(s): Alejandra Valdivia, Charity Duran, Alejandra San Martin.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 41 , 2015

Abstract:

Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions, such as migration and adhesion. The effects of Nox-derived ROS on cytoskeletal remodeling may be largely attributed to the ability of ROS to directly modify proteins that constitute or are associated with the cytoskeleton. Additionally, Nox-derived ROS may participate in signaling pathways governing cytoskeletal remodeling. In addition to these more extensively studied signaling pathways involving Nox-derived ROS, there also exist redox sensitive pathways for which the source of ROS is unclear. ROS from as of yet undetermined sources play a role in modifying, and thus regulating, the activity of several proteins critical for remodeling of the actin cytoskeleton. In this review we discuss ROS sensitive targets that are likely to affect cytoskeletal dynamics, as well as the potential involvement of Nox proteins.

Keywords: Cytoskeleton, NADPH oxidase, ROS, oxidation, signaling.

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Article Details

VOLUME: 21
ISSUE: 41
Year: 2015
Page: [6009 - 6022]
Pages: 14
DOI: 10.2174/1381612821666151029112624
Price: $58

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