Background: Benzimidazoles exhibit a wide range of biological activities, including antiparasitic,
antiulcer, antihypertensive, antihistaminic, anticancer, antiemetic and antiinflammatory agents.
Methods: Tetraethylammonium superoxide has been generated in situ by the phase transfer reaction of
potassium superoxide and tetraethylammonium bromide in dry dimethylformamide at room temperature
and subsequently allowed to react with a number of Schiff's bases.
Results: The Synthesis of 2-arylbenzimidazoles from Schiff bases using in situ generated tetraethylammonium superoxide
in dry DMF, at room temperature.
Conclusion: The role of in situ generated Et4NO2 as an efficient agent to promote the synthesis of 2-arylbenzimidazole
from Schiff base has been demonstrated under mild conditions.