Superoxide Ion Promoted Synthesis of 2-Arylbenzimidazoles from Schiff Bases

Author(s): Raghvendra S. Raghuvanshi , Virendra P. Yadav , Vinod K. Singh .

Journal Name: Letters in Organic Chemistry

Volume 13 , Issue 1 , 2016

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Abstract:

Background: Benzimidazoles exhibit a wide range of biological activities, including antiparasitic, antiulcer, antihypertensive, antihistaminic, anticancer, antiemetic and antiinflammatory agents.

Methods: Tetraethylammonium superoxide has been generated in situ by the phase transfer reaction of potassium superoxide and tetraethylammonium bromide in dry dimethylformamide at room temperature and subsequently allowed to react with a number of Schiff's bases.

Results: The Synthesis of 2-arylbenzimidazoles from Schiff bases using in situ generated tetraethylammonium superoxide in dry DMF, at room temperature.

Conclusion: The role of in situ generated Et4NO2 as an efficient agent to promote the synthesis of 2-arylbenzimidazole from Schiff base has been demonstrated under mild conditions.

Keywords: Benzimidazole, oxidative cyclization, superoxide.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2016
Page: [67 - 70]
Pages: 4
DOI: 10.2174/1570178612666151028210206

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