P300 Wave in Depression: An Update
Pp. 25-49 (25)
Ravi Prakash, Srinivasa R. and Priyanka Rastogi
Event related potentials (ERP) are generated in response to a distinct episode
such as when a sensory stimulus is present or there is cognitive reaction for such a
stimulus. The electrical potentials generated from such motor, sensory or cognitive
events are called electroencephalographic (EEG) fluctuation. Electrically, these are the
reflection of the combined activity of postsynaptic potentials generated by huge number
(measuring thousands or millions in number) of cortical pyramidal neurons which are
oriented in a similar manner and are firing in synchrony. Among all the event related
potentials, the best studied has been that of the positive wave arising at around 300 ms,
popularly known as the P300. The P300 is the positive wave appearing at about 300 ms
after presentation of stimulus. This ERP component was first explained by Sutton et al.
and is extensively examined in relation to neurophysiological evaluation of cognitive
functions. They described this waveform in terms of amplitude, polarity and latency.
Many studies have reported that depressed individuals have distinctive cognitive
impairment. The impact of these findings was such that the cognitive impairment of
decreased ability to concentrate has become one of the nine core DSM-IV diagnostic
criteria for major depressive disorder as a characteristic feature of syndromal
depression. Perhaps next to schizophrenia, depression has been the most studied
psychiatric condition to be evaluated with P300. So far, more than 20 studies have
analysed the P300 component in depressed individuals and have unanimously pointed
that depression causes an attenuated P300 response for different stimulus types and
sensory modalities-auditory tones, geometric shapes, alphanumeric characters, nonsense
syllables and photographs. The use of P300 in depression has been mainly for two
purposes- 1) Diagnostic and 2) Prognostic. In this review, we will elaborate these
findings of P300 in depression and their applications.
Depression, event related potential, P300 wave.
Department of Physiology M.S. Ramaiah Medical College, Bangalore, India.