Abstract
Chemotherapy is the major and most widely used therapeutic strategy for the treatment of a wide variety of cancers. The non-specific/non-targeted drug delivery in chemotherapy leads to undesired side effects in normal and healthy tissues, and insufficient dosages to kill cancerous cells. Now-a-days, smart and intelligent multifunctional targeted nanomedicines based on various nanocarriers (dendrimers, carbon nanotubes, graphene, nanoparticles, quantum dots, self-emuslifying lipidic systems and carbon nanohorns etc) are being investigated promisingly in cancer treatment. In this article, we review the role of smart and intellegent multifucntional nanocarriers in delivery of chemotherapeutic agents with the aim to develop promising treatment strategy to combat with one of the killer of man kind i.e. cancer.
Keywords: Chemotherapy, multifunctional, dendrimers, carbon nanotubes, drug delivery, drug targeting.
Current Pharmaceutical Design
Title:Design of multifunctional nanocarriers for delivery of anti-cancer therapy
Volume: 21 Issue: 42
Author(s): Neelesh Kumar Mehra, Keerti Jain and Narendra Kumar Jain
Affiliation:
Keywords: Chemotherapy, multifunctional, dendrimers, carbon nanotubes, drug delivery, drug targeting.
Abstract: Chemotherapy is the major and most widely used therapeutic strategy for the treatment of a wide variety of cancers. The non-specific/non-targeted drug delivery in chemotherapy leads to undesired side effects in normal and healthy tissues, and insufficient dosages to kill cancerous cells. Now-a-days, smart and intelligent multifunctional targeted nanomedicines based on various nanocarriers (dendrimers, carbon nanotubes, graphene, nanoparticles, quantum dots, self-emuslifying lipidic systems and carbon nanohorns etc) are being investigated promisingly in cancer treatment. In this article, we review the role of smart and intellegent multifucntional nanocarriers in delivery of chemotherapeutic agents with the aim to develop promising treatment strategy to combat with one of the killer of man kind i.e. cancer.
Export Options
About this article
Cite this article as:
Mehra Kumar Neelesh, Jain Keerti and Jain Kumar Narendra, Design of multifunctional nanocarriers for delivery of anti-cancer therapy , Current Pharmaceutical Design 2015; 21 (42) . https://dx.doi.org/10.2174/1381612821666151027153106
DOI https://dx.doi.org/10.2174/1381612821666151027153106 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Aspartic Protease Inhibitors: Effective Drugs against the Human Fungal Pathogen Candida albicans
Mini-Reviews in Medicinal Chemistry Management of Ovarian Cancer In Younger Women
Reviews on Recent Clinical Trials Microarrays and the Genetic Analysis of Brain Tumors
Current Genomics Natural Bio-Drugs as Matrix Metalloproteinase Inhibitors: New Perspectives on the Horizon?
Recent Patents on Anti-Cancer Drug Discovery Microbial Polysaccharides and their Derivatives as Current and Prospective Pharmaceuticals
Current Pharmaceutical Design Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential
Protein & Peptide Letters Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers
Current Medicinal Chemistry A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism
Current Pharmaceutical Design Polypharmacology of Approved Anticancer Drugs
Current Drug Targets Telomere Recombination and the ALT Pathway: A Therapeutic Perspective for Cancer
Current Pharmaceutical Design Phosphorothioate-Stimulated Uptake of siRNA by Mammalian Cells: A Novel Route for Delivery
Current Topics in Medicinal Chemistry Separation of Ginseng Active Ingredients and their Roles in Cancer Metastasis Supplementary Therapy
Current Drug Metabolism Angiotensin II, Cell Proliferation and Angiogenesis Regulator: Biologic and Therapeutic Implications in Cancer
Current Vascular Pharmacology Antibody-Drug Conjugate Targets
Current Cancer Drug Targets NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation
Current Immunology Reviews (Discontinued) Advances in Methods for Therapeutic Peptide Discovery, Design and Development
Current Pharmaceutical Biotechnology Stable Expression of the Sodium/Iodide Symporter (NIS) for anti-Cancer Gene Therapy of Glioma Cells Using a Third Generation Self-Inactivating Lentiviral Vector System in Combination with 211At
Current Radiopharmaceuticals Natural Products as Anti-Invasive and Anti-Metastatic Agents
Current Medicinal Chemistry Mesenchymal Stem Cell Therapy for Equine Tendinitis
Recent Patents on Regenerative Medicine Gap Junctions as Targets for Cancer Chemoprevention and Chemotherapy
Current Drug Targets