Recent Advances in the Synthesis of Coumarin Derivatives via Pechmann Condensation

Author(s): Abhay S. Zambare , Firoz A. Kalam Khan , Sureshchandra P. Zambare , Shantanu D. Shinde , Jaiprakash N. Sangshetti .

Journal Name: Current Organic Chemistry

Volume 20 , Issue 7 , 2016

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Abstract:

The Pechmann condensation is the formation of coumarin derivatives from phenols and a carboxylic acids or esters containing a β-carbonyl group under acidic conditions. The reaction has attracted a great deal of attention because of the biological significance of coumarins derivatives. As a result, the synthesis of coumarin and its derivatives have been an attractive goal for the chemist. The present review is focused on brief aspects of the synthesis of coumarin derivatives from phenols and a carboxylic acids or esters containing a β-carbonyl group under acidic conditions using various catalysts.

Keywords: Pechmann condensation, coumarins derivatives, heterogeneous catalyst, ionic liquids, microwave, ultrasound, biological activity.

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Article Details

VOLUME: 20
ISSUE: 7
Year: 2016
Page: [798 - 828]
Pages: 31
DOI: 10.2174/1385272820666151026224227
Price: $58

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