The formations of cell-in-cell structures have been found in several important biological processes.
Recent studies have shed light on the biochemical signaling pathways as well as the quantitative
understandings of the underlying physics. Multiple new features that regulate the cellular engulfment have
been identified. However, the driving forces promoting the structural formation are still under debate. This
review focuses on the recent progress and discusses the potential significance of the existing physical models.
Keywords: Cell-in-cell, entosis, phagocytosis, cytoskeleton, Rho GTPase, actomyosin.
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