Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in
epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by
invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are
internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death,
that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current
understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
Keywords: Cell-in-cell, entosis, entotic cell death, cannibalism, phagocytosis, engulfment, autophagy, LAP, cell
Rights & PermissionsPrintExport