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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

Author(s): O. Florey, S. E. Kim and M. Overholtzer

Volume 15, Issue 9, 2015

Page: [861 - 866] Pages: 6

DOI: 10.2174/1566524015666151026100042

Price: $65

Abstract

Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.

Keywords: Cell-in-cell, entosis, entotic cell death, cannibalism, phagocytosis, engulfment, autophagy, LAP, cell competition.


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