Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

Author(s): Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner, Gyorgy Keglevich.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 6 , 2016

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Abstract:

An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.

Keywords: Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [475 - 478]
Pages: 4
DOI: 10.2174/1570180812666151022221805

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