An efficient method was developed for the synthesis of pamidronic acid
involving the reaction of β-alanine with three equivalents of phosphorus trichloride
and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents
of [BMIM][PF6] as an additive.
Keywords: Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.
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