Pillar[n]arenes, a new star of macrocyclic hosts since it was firstly reported in 2008 by Nakamoto group,
have obtained a lot of attention due to their unique and intriguing characteristics and properties. The study of synthetic
approaches to design and construct pillar[n]arenes is a significant aspect in pillar[n]arene chemistry. Up to
now, routes to prepare pillar[n]arenes or functioned pillar[n]arene derivatives are very mature and diversified. In
this review, we summarized the synthesis of pillar[n]arenes and pillar[n]arenes derivatives. With the development
of host-guest chemistry, we expect to develop functioned pillar[n]arenes, not only in expanding sophisticated and
novel structures like rotaxanes, but also in biological applications such as artificial transmembrane channels, controllable
delivery systems and so on.