Radiotherapy in Transitional Cell Carcinoma of Urinary Bladder Cancer –Where Does it Fit Into Treatment Protocol

Author(s): Rony Benson, Supriya Mallick, K.P. Haresh, P.K. Julka, G.K. Rath.

Journal Name: Current Cancer Therapy Reviews

Volume 11 , Issue 2 , 2015

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Abstract:

Urinary bladder carcinoma is estimated to be the ninth most common cause of cancer worldwide. The treatment of bladder carcinoma is an area of active research owing to lack of evidence of any treatment modality. Traditionally surgery, cystectomy, was considered the cornerstone of therapy. However, the morbidity of such approach has paved for bladder preservation approach with radiation in combination with chemotherapy. The use of transurethral resection of bladder tumor along with radiation and chemotherapy helps patients to have a functional bladder without compromising survival. Adjuvant radiation is an underutilized treatment modality. In the present era availability of sophisticated radiation technique allows delivery of radiation without increasing toxicity. Hence, adjuvant radiation may be used for patients with R1 resection and lymph node positive disease alone or in combination with chemotherapy. Radiation also appears a valuable treatment option for palliation in bladder tumor. We herein intend to review the present place of radiation in the management of transitional cell carcinoma of urinary bladder.

Keywords: Bladder carcinoma, chemo-radiotherapy, locally advanced.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2015
Page: [94 - 101]
Pages: 8
DOI: 10.2174/1573394711666151022203201
Price: $58

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