Abstract
Background: It is well established that there is an important genetic predisposition for type 2 diabetes mellitus (T2DM).
Objective: To summarise available epidemiological data regarding T2DM transmission in various populations.
Method: Narrative review.
Results: The estimated risk for the diagnosis of T2DM increases approximately by 2-4 times, when father, mother or both have this condition. Conversely, many T2DM patients have family members with DM. Studies have suggested that the likelihood of T2DM in the next generation is higher in the event of a diabetic mother than father. Both genetic factors, such as mitochondrial DNA mutations, and environmental components, such as intra-uterine environment, have been implicated in the higher maternal transmission of T2DM. Despite the above findings, some studies in populations with high frequency of T2DM have not corroborated the predominantly maternal transmission. Such works have shown either an excess paternal or an equal transmission of T2DM.
Conclusion: It appears that potential biases in reporting family history data, especially between the various racial groups, have contributed to the controversy over the existence of excess maternal transmission of DM.
Keywords: Family history, maternal diabetes, paternal diabetes, type 2 diabetes mellitus.
Current Diabetes Reviews
Title:Family History of Type 2 Diabetes: Does Having a Diabetic Parent Increase the Risk?
Volume: 13 Issue: 1
Author(s): A. K. Papazafiropoulou, N. Papanas, A. Melidonis and E. Maltezos
Affiliation:
Keywords: Family history, maternal diabetes, paternal diabetes, type 2 diabetes mellitus.
Abstract: Background: It is well established that there is an important genetic predisposition for type 2 diabetes mellitus (T2DM).
Objective: To summarise available epidemiological data regarding T2DM transmission in various populations.
Method: Narrative review.
Results: The estimated risk for the diagnosis of T2DM increases approximately by 2-4 times, when father, mother or both have this condition. Conversely, many T2DM patients have family members with DM. Studies have suggested that the likelihood of T2DM in the next generation is higher in the event of a diabetic mother than father. Both genetic factors, such as mitochondrial DNA mutations, and environmental components, such as intra-uterine environment, have been implicated in the higher maternal transmission of T2DM. Despite the above findings, some studies in populations with high frequency of T2DM have not corroborated the predominantly maternal transmission. Such works have shown either an excess paternal or an equal transmission of T2DM.
Conclusion: It appears that potential biases in reporting family history data, especially between the various racial groups, have contributed to the controversy over the existence of excess maternal transmission of DM.
Export Options
About this article
Cite this article as:
Papazafiropoulou K. A., Papanas N., Melidonis A. and Maltezos E., Family History of Type 2 Diabetes: Does Having a Diabetic Parent Increase the Risk?, Current Diabetes Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573399812666151022143502
DOI https://dx.doi.org/10.2174/1573399812666151022143502 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
DGAT: Novel Therapeutic Target for Obesity and Type 2 Diabetes Mellitus
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Subject Index to Volume 1
Current Alzheimer Research Chronic Complications of Diabetes Mellitus: A Mini Review
Current Diabetes Reviews The Prothrombotic State in Hypertension and the Effects of Antihypertensive Treatment
Current Pharmaceutical Design Maternal Sepsis: Current Approaches to Recognition and Clinical Management
Current Women`s Health Reviews Cardiovascular Changes in Menopause
Current Cardiology Reviews Biomarkers Associated with Stroke Risk in Atrial Fibrillation
Current Medicinal Chemistry Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities
Current Pharmaceutical Design Interferons: Mechanisms, Biological Activities and Survey of their Use in Human Diseases
Current Bioactive Compounds Cell-Permeable Peptide Inhibitor of c-Jun NH2-Terminal Kinase for the Treatment of Diabetes
Current Bioactive Compounds Nutraceuticals: Beyond the Diet Before the Drugs
Current Bioactive Compounds The Antioxidant Activity of Coumarins and Flavonoids
Mini-Reviews in Medicinal Chemistry A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry
Current Pharmaceutical Design Investigating the Associations between Mediterranean Diet, Physical Activity and Living Environment with Childhood Asthma using Path Analysis
Endocrine, Metabolic & Immune Disorders - Drug Targets Current Approach to the Diagnosis and Treatment of Femoral-Popliteal Arterial Disease. A Systematic Review
Current Cardiology Reviews Application of Resveratrol in Diabetes: Rationale, Strategies and Challenges
Current Molecular Medicine QSAR Studies of PTP1B Inhibitors: 1, 2-Naphthoquinone Derivatives
Letters in Drug Design & Discovery Application of Factorial Design and Study of Photodegradation Kinetics for the Determination of Sitagliptin by Capillary Electrophoresis
Current Analytical Chemistry Structures Required of Polyphenols for Inhibiting Advanced Glycation end Products Formation
Current Drug Metabolism T9-T10 Osteomyelitis, Epidural Abscess and Cord Compression Secondary to <i>Mycobacterium abscessus</i>: A Case Report
Infectious Disorders - Drug Targets